ABNORMAL ALFENTANIL PHARMACOKINETICS

Pharmacokinetics of alfentanil during and after a fixed rate infusion.

Twenty-nine patients (age range 14-81 yr) undergoing orthopaedic surgery received alfentanil 100 micrograms kg-1 given as two i.v. boluses followed by a fixed rate infusion of 1 micrograms kg-1 min-1 for 44-445 min. Additional 1-mg bolus doses of alfentanil were administered as required. Plasma samples were assayed for alfentanil using radioimmunoassay. Pharmacokinetic parameters were estimated...

The pharmacokinetics of fentanyl, sufentanil and alfentanil: a comparative review.

Pharmacokinetics of the infusion of alfentanil in man.

The pharmacokinetics of alfentanil under the conditions of an empirically derived 1-h continuous infusion of 3 micrograms kg-1 min-1, with a bolus of 80 micrograms kg-1, both i.v., were determined in five patients. The distribution half-life (mean +/- SD) (7.4 +/- 3.1 min), elimination half-life (86.7 +/- 15.8 min), apparent volume of distribution, Varea (0.44 +/- 0.15 litre kg-1) and eliminati...

Mixed-effects modeling of the influence of alfentanil on propofol pharmacokinetics.

BACKGROUND The influence of alfentanil on the pharmacokinetics of propofol is poorly understood. Therefore, the authors studied the effect of a pseudo-steady state concentration of alfentanil on the pharmacokinetics of propofol. METHODS The pharmacokinetics of propofol were studied on two occasions in eight male volunteers in a randomized crossover manner with a 3-week interval. While volunte...

Pharmacokinetics and effects of i.m. alfentanil as premedication for day-case ophthalmic surgery in elderly patients.

We have studied the pharmacokinetics and effects of i.m. alfentanil as premedication for peribulbar block in 90 patients undergoing elective day-case cataract surgery. We compared alfentanil 12.5 micrograms kg-1 injected into the deltoid (n = 30) or gluteal muscle (n = 30) 15 min before the peribulbar block, and placebo (n = 30). The alfentanil concentrations were significantly greater in the d...